The Peptide leadership at ChemPartner San Francisco offers a unique blend of US based project team leadership with the cost effective backing of a 30+ strong Peptide chemistry group located in Shanghai, China. Our projects are truly partnered with biotech and pharmaceutical clients, both large and small, to advance therapeutic candidates. The ChemPartner team excels in combining peptide design and synthesis efforts to drive projects forward and efficiently deliver on client specified design goals and project timelines. Multiple client projects have been successfully executed through the CP-SF and Shanghai based Peptides blended team.
- The US based Peptide leadership offers:
- Leaders with > 20 years of experience leading therapeutic peptide discovery programs at US based biotech and pharmaceutical companies
- Expertise in peptide chemistry, including solid phase and liquid phase peptide synthesis, peptide conjugates and peptidomimetics, as well as new bioconjugation techniques
- Efficient collaboration between US and Shanghai team to thoroughly review data, troubleshoot technical issues and deliver results with data driven recommendations on strategy and path forward
- Strong and open lines of communication in all directions: with clients, Shanghai based team leaders and scientists
- Biweekly project team meetings, slide presentations and access to up to date project status and availability for discussions during normal business hours in North America
- Fully equipped Biotage Syro II parallel peptide synthesizer with heating & inert gas
- Supporting purification and analytical capability for synthetic route scouting and method development for efficient method transfer to Shanghai team
- Peptide Design and Synthesis Support Capabilities including:
- Peptide Design in SF coupled with Computational design in SF and Shanghai
- Peptide Drug Design and Stabilization
- Lead Optimization
- Solubility testing
- Client Consultation on Project Scoping
- Feasibility Studies
- Synthesis method development
- Process Development and Scaleup
- The Shanghai based Peptide team offers:
- 2 Biotage Syro II parallel peptide synthesizers to enable small and large library syntheses
- Strong group leadership with > 20 years experience in peptide synthesis, characterization and conjugation combined with strong building block synthesis skills
- Peptide Synthesis Expertise:
- Macrocycles & macrocycle libraries
- Multiple disulfide bridged peptides
- Hydrocarbon bridge “stapled” peptides
- 1,2,3-Triazole cyclic or bridged peptides via click reaction
- Novel linker synthesis & novel peptide backbone modifications
- N-and C-terminal and side-chain modifications
- Unnatural amino acid building blocks synthesis and peptide incorporation
- Labeled peptides
- Peptide conjugates
- Cyclic peptides
- Peptide libraries
- Peptide Synthesis Capabilities:
- Peptide synthesis scale: up to 5 g
- Unnatural amino acid building blocks synthesis scale: up to 20 g
- MW range: up to 100 amino acids
- Purity: 85 % – 99 % as needed by client
- Salt exchange
- Circular Dichroism for % helicity determination
- QC: LCMS (identity) and RP-HPLC (purity)
- AAA, nitrogen content, salt content, water content upon request
- Timeline: 2-3 weeks for standard synthesis or small library production; 1-2 weeks additional for synthesis or purification method development work
- Fully equipped peptide synthesis, purification and characterization capabilities including:
- 2 Biotage Syro II parallel peptide synthesizers to enable small and large library syntheses
- 2 Waters Autopure mass directed purification systems and 1 UV-driven system
- Other supporting purification and analytical capability for complex library support
- Access to Triple TOF 5600 and QE mass spectrometers
- COA including LCMS and HPLC characterization of all synthesized peptides