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Pharmacokinetics

Home DMPK / Exploratory Toxicology DMPK / Exploratory Toxicology Pharmacokinetics

Pharmacokinetics

Overview:

  • AAALAC and OLAW accredited animal facilities with access to broad ranges of animal species
  • State of the art instruments
  • Extensive experiences in PK model development with comprehensive in vivo technique such as surgical operation and animal care
  • Formulation support for in vivo studies including formulation screen, development and formulation recommendation for various species and strains
  • PK/PD data analysis, modeling, and simulation
  • Regulatory filing support

Animal species

  • Mouse, rat, Guinea pig,  gerbil, hamster, rabbit, ferret, dog, monkey and mini pig

Dose Route

  • IV, PO, SC, IP, IM, IV infusion, SC infusion, intranasal (IN) and intracerebral ventricular (ICV), rectal, topical administration etc.

Sampling

  • Tail vein, foot dorsal vein, femoral vein, facial vein, submandibular, CSF (cisternae; spinal cord), tear, lymph, all tissues etc.

Comprehensive Surgery Techniques

  • Portal vein cannulation
  • Mesenteric lymph duct cannulation
  • Bile duct cannulation (rat, dog, and monkey)
  • Intraduodenal administration
  • Terminal CSF collection (mice) and survival CSF collection ( rat, mini pigs, dog, and monkey)

Biological matrix

  • Blood, plasma, urine, tissue, CSF, brain, sciatic nerve, DRG, lymph node, bone marrow and all other tissues.

Formulation development

  • Clear solution strategy for IV dosing
  • Suspension formulation strategy for chronic toxicity study
  • Simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) dilution study for in vivo precipitation and super-saturation prediction
  • Advanced formulation approach (microsuspension, nanosuspension or solid dispersion)
  • Service Overview
  • Discovery Chemistry
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      • OncoCP Database
    • Pathology Core Facility
      • Histopathology
      • Molecular Pathology
    • Immunology
      • Primary immune cell assays
      • Immune cell line assays
      • Autoimmune disease models
      • In vivo PD models
      • Immune profiling for MOA
    • Tumor Immunology
    • Neuroscience
      • Volume Discount Fast services for Neuroscience
      • Behavioral Pharmacology
      • In vivo Pain Models
      • Non-Human Primate Cognition
      • In Vitro Electrophysiology
    • Cell Biology
      • Target Validation
      • Cell-based Assays
      • Cancer Cell Line Panel Screen
      • Biomarker Analysis
    • In Vitro Biology
      • Kinases
      • Epigenetics
      • GPCR, NR, Ion-channel, Transporter
      • Ubiquitin & PROTAC
      • KRAS
      • COVID-19
      • Radiometric
      • Customized assay development
      • High throughput screening
      • MOA Study
    • Metabolic & Cardiovascular Diseases
  • DMPK / Exploratory Toxicology
    • DMPK / Exploratory Toxicology
      • In vitro ADME
      • Pharmacokinetics
      • Exploratory Toxicology
      • Bioanalysis
      • Regulatory filing
    • Biomarkers, Preclinical & Clinical Sample Bioanalysis
    • Large molecule PK/BA services
      • Monoclonal Antibodies
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      • Proteins & Peptides
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  • Biologics Discovery
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      • Antibody Engineering
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      • Antibody-Drug Conjugate
    • Protein Science
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      • mAb Release Tests and Extended Characterization
      • Antibody-Drug Conjugate(ADC) Analysis
      • Therapeutic Protein Characterization
      • Biomolecular Interaction Analysis
    • B Cell Cloning
  • Biologics CMC
    • Stable Cell Line Development
    • Process Development
    • Formulation Development
    • Aseptic Filling and Freeze-drying
    • Drug Developability / Manufacturability study
    • Final Container Extractables & Leachables Study
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    • Process R&D Services
    • Process Safety
    • Analytical Development
    • Pre-Formulation Development
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    • Manufacturing

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