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Fragment Based Screening

Home Discovery Chemistry Fragment Based Screening

Fragment Based Screening

The Fragment Based Screening Service at ChemPartner is dedicated to providing a cost-effective and high quality lead generation solutions for clients. The FBS team has deep a understanding of the pharmaceutical sciences and they excel in combining lead generation solutions, such as fragment based screening with Chemistry, Biology and Biologics to drive projects forward efficiently.

FBS Capabilities 

Screening

    • Ligand Observe NMR methods
      • Saturation Transfer Difference (STD)
      • waterLOGSY (wLOGSY)
      • Carr-Purcell-Meiboom-Gill (CPMG)

Library preparation(either in house fragment library or client provided)

      • Identity, solubility, purity
      • Automated smart pooling
      • Positive control at regular intervals

Follow-up analysis

      • Validation (follow-up singletons)
      • Rank-order; cluster

Target Generation

      • Protein synthesis and purification

Target Preparation

      • Screen design
      • Sample optimization
      • Experimental optimization

Complimentary Capabilities

      • Orthogonal screening methods e.g. SPR, TSA
      • X-Ray Crystallography
      • Computational Chemistry
      • Chemical elaboration to support optimization
      • Biological Assays design and support

Fragment Library Screening Options

Fragment Library – Commercial and Proprietary

Our fragment based library of >2000 compounds is a combination of:

  • Proprietary fragments from internal small molecule collections
  • Proprietary fragments designed from FDA approved drugs
  • 19F- containing fragments
  • Covalent fragments
  • Commercial fragments

We are also able to screen libraries of fragments provided by our clients:


Screening external libraries

  • Client-provided
  • Client-selected commercial libraries
  • Custom commercial libraries

Additional capabilities

      • NMR-based compound quality check
        • Identity
        • Purity
        • Solubility
      • Fragment pooling
        • Randomized pooling
        • Smart pooling

Versatile Biophysical Screening Methods

Our primary recommendation is to conduct an initial fragment screen using NMR as a the primary technique with confirmation by orthogonal methods. ChemPartner has access to high field NMR (600MHz or 700MHz) with cryoprobe technology

      • NMR STD
      • NMR wLOGSY, CPMG
      • 19F NMR
      • TSA, SPR

Fragment hits using three NMR techniques

  • Service Overview
  • Discovery Chemistry
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    • Fragment Based Screening
    • Computer Aided Drug Design
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    • Protein Structure
  • Biology & Pharmacology
    • Oncology
      • OncoCP Database
    • Pathology Core Facility
      • Histopathology
      • Molecular Pathology
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      • Primary immune cell assays
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      • In vivo PD models
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    • Tumor Immunology
    • Neuroscience
      • Volume Discount Fast services for Neuroscience
      • Behavioral Pharmacology
      • In vivo Pain Models
      • Non-Human Primate Cognition
      • In Vitro Electrophysiology
    • Cell Biology
      • Target Validation
      • Cell-based Assays
      • Cancer Cell Line Panel Screen
      • Biomarker Analysis
    • In Vitro Biology
      • Kinases
      • Epigenetics
      • GPCR, NR, Ion-channel, Transporter
      • Ubiquitin & PROTAC
      • KRAS
      • COVID-19
      • Radiometric
      • Customized assay development
      • High throughput screening
      • MOA Study
    • Metabolic & Cardiovascular Diseases
  • DMPK / Exploratory Toxicology
    • DMPK / Exploratory Toxicology
      • In vitro ADME
      • Pharmacokinetics
      • Exploratory Toxicology
      • Bioanalysis
      • Regulatory filing
    • Biomarkers, Preclinical & Clinical Sample Bioanalysis
    • Large molecule PK/BA services
      • Monoclonal Antibodies
      • Antibody Drug Conjugates
      • Bispecific Antibodies
      • Proteins & Peptides
      • Immunogenicity
  • Biologics Discovery
    • Antibody Discovery
      • Hybridoma
      • Antibody Engineering
      • Phage Display
      • Antibody-Drug Conjugate
    • Protein Science
    • Biologics Analytical Services
      • mAb Release Tests and Extended Characterization
      • Antibody-Drug Conjugate(ADC) Analysis
      • Therapeutic Protein Characterization
      • Biomolecular Interaction Analysis
    • B Cell Cloning
  • Biologics CMC
    • Stable Cell Line Development
    • Process Development
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    • Aseptic Filling and Freeze-drying
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  • Small Molecule CMC
    • Process R&D Services
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    • Pre-Formulation Development
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    • Manufacturing

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