• 中文版
  • Home
  • About Us
    • Contract Research Organization
    • Contract Development and Manufacturing Organization
    • Accolades
    • Publications
  • Services Overview
  • Discovery Chemistry
    • Synthetic Chemistry
    • Medicinal Chemistry
    • Library Chemistry
    • Peptide Chemistry
    • Fragment Based Screening
    • Computer Aided Drug Design
    • Analytical Services
    • Protein Structure
  • Biology & Pharmacology
    • Oncology
    • Pathology Core Facility
    • Immunology
    • Tumor Immunology
    • Neuroscience
    • Cell Biology
    • In Vitro Biology
      • Kinases
      • Epigenetics
      • GPCR, NR, Ion-channel, Transporter
      • Ubiquitin & PROTAC
      • KRAS
      • COVID-19
      • Radiometric
      • Customized assay development
      • High throughput screening
      • MOA Study
    • Metabolic & Cardiovascular Diseases
  • DMPK / Exploratory Toxicology
    • DMPK / Exploratory Toxicology
    • Biomarkers, Preclinical & Clinical Sample Bioanalysis
    • Large molecule PK/BA services
  • Biologics Discovery
    • Antibody Discovery
    • Protein Science
    • Biologics Analytical Services
    • B Cell Cloning
  • Biologics CMC
    • Stable Cell Line Development
    • Process Development
    • Formulation Development
    • Aseptic Filling and Freeze-drying
    • Drug Developability / Manufacturability study
    • Final Container Extractables & Leachables Study
    • Analytical Development and Testing
    • GMP Production
  • Small Molecule CMC
    • Process R&D Services
    • Process Safety
    • Analytical Development
    • Pre-Formulation Development
    • Formulation Development
    • ICH Stability Studies
    • CMC CTD Support
    • Manufacturing
  • Blog
  • Careers
  • News & Events
    • Webinars
  • Contact Us
  • Download Center

Call us today! +86 21 5132 0088

contact@chempartner.com
中文版
Shanghai ChemPartner Shanghai ChemPartner Shanghai ChemPartnerShanghai ChemPartner
  • Home
  • About Us
    • About ChemPartner
    • CRO
    • CDMO
    • Accolades
    • Publications
  • Services
    • Discovery Chemistry
      • Synthetic Chemistry
      • Medicinal Chemistry
      • Library Chemistry
      • Peptide Chemistry
      • Fragment Based Screening
      • Computer Aided Drug Design
      • Analytical Services
      • Protein Structure
    • Biology & Pharmacology
      • Oncology
      • Pathology Core Facility
      • Immunology
      • Tumor Immunology
      • Cell Biology
      • In Vitro Biology
      • Neuroscience
      • Metabolic & Cardiovascular Diseases
      • Epigenetics
    • DMPK / Exploratory Toxicology
      • DMPK / Exploratory Toxicology
      • Biomarkers, Preclinical & Clinical Sample Bioanalysis
      • Large molecule PK/BA services
    • Biologics Discovery
      • Antibody Discovery
      • Protein Science
      • Biologics Analytical Services
      • B Cell Cloning
    • Biologics CMC
      • Stable Cell Line Development
      • Process Development
      • Formulation Development
      • Aseptic Filling and Freeze-drying
      • Drug Developability / Manufacturability study
      • Final Container Extractables & Leachables Study
      • Analytical Development and Testing
      • GMP Production
    • Small Molecule CMC
      • Process R&D Services
      • Process Safety
      • Analytical Development
      • Pre-Formulation Development
      • Formulation Development
      • ICH Stability Studies
      • CMC CTD Support
      • Manufacturing
  • Blog
  • Careers
  • News & Events
    • Webinars
  • Contact Us
  • Download Center

Metabolic & Cardiovascular Diseases

Home Biology & Pharmacology Metabolic & Cardiovascular Diseases

Metabolic & Cardiovascular Diseases

With well skills and experience in metabolic research field, we provide the pharmacodynamics and pharmacological study for your preclinical candidates. By using our invivo animal models of human disease, together with in vitro assay, we facilitate our customers to evaluate efficacy and mechanism of action of drug candidates. We also have strong capability to provide customized services of new assays and animal models based on the literature. Our services include but not limited to

In vitro Assays

  • Anti-oxidation activity screening platforms
  • Inhibitory activity assay against the PCSK9/LDLR interaction
  • DPPIV inhibitory activity assay
  • Glucose Stimulated Insulin Secretion assay (GSIS)

In vivo Animal Models

Diabetes & Obesity

  • db/db mice
  • ob/ob mice
  • Zucker Diabetic Fatty (ZDF) Rats
  • High-fat diet-induce obesity (DIO)
  • Streptozocin/HFD+STZ induced diabetes models

Measurement:

  • Blood glucose, insulin
  • Urine glucose, HbA1c
  • Glucose tolerance test  and insulin tolerance test (GTT, ITT)
  • Food intake and effect on body weight

Nephropathy

  • Unilateral ureter obstruction (UOO) kidney fibrosis model
  • Diabetic nephropathy model
  • Acute kidney injury (Ischemia-reperfusion)
  • Ade-induced chronic kidney injury
  • Chronic kidney disease with 5/6 nephrectomy in mice

Measurement:

  • Glomerular Filtration Rate GFR
  • 24 hour albuminuria, proteinuria, urine glucose
  • Inflammation marker: TGF-β1, IL-6
  • Kidney function and marker: CRE, BUN, UA, Kim-1, renin
  • HE or PAS pathology staining

Cardiovascular Disease

  • Hypertension: Spontaneously Hypertensive Rat (SHR) / salt induced hypertension in Dahl rats
  • High fat diet induced atherosclerosis in ApoE -/- mice
  • Golden hamster hyperlipidemia model

Measurement:

  • A tail-cuff system-BP2000 Blood pressure analysis
  • Lipid profiling: TC, TG, LDL, HDL
  • En-face Oil red O staining
  • Histology analysis: HE or Oil red stain

Liver Disease

  • Methionine-and choline-deficient (MCD) diet induced NAFLD/NASH model
  • High fat, high cholesterol, high sucrose (HFCS) diet induced NAFLD/NASH model
  • High fat diet  + carbon tetrachloride CCl4 induced NAFLD/NASH model
  • CCl4 induced acute liver injury and liver fibrosis
  • Drug induced acute liver injury

Measurement:

  • Body weight, liver weigh
  • Liver histological analysis (H&E,  Sirius Red, tri chrome staining)
  • liver  function -serum ALT, AST, ALP
  • serum and liver lipid profile
  • Fibrosis marker- hyaluronic acid, a-SMA
  • Inflammation biomarker: TNF-a, IL-1b, MCP-1, TGF-b1, IL6,IL8, sCD14
  • Histopathology analysis and score

Case study

  • Case study: diabetes

 

  • Case study: hypertension

  • Case study: diabetic nephropathy

  • Case study: atherosclerosis

  • Service Overview
  • Discovery Chemistry
    • Synthetic Chemistry
    • Medicinal Chemistry
    • Library Chemistry
    • Peptide Chemistry
    • Fragment Based Screening
    • Computer Aided Drug Design
    • Analytical Services
    • Protein Structure
  • Biology & Pharmacology
    • Oncology
      • OncoCP Database
    • Pathology Core Facility
      • Histopathology
      • Molecular Pathology
    • Immunology
      • Primary immune cell assays
      • Immune cell line assays
      • Autoimmune disease models
      • In vivo PD models
      • Immune profiling for MOA
    • Tumor Immunology
    • Neuroscience
      • Volume Discount Fast services for Neuroscience
      • Behavioral Pharmacology
      • In vivo Pain Models
      • Non-Human Primate Cognition
      • In Vitro Electrophysiology
    • Cell Biology
      • Target Validation
      • Cell-based Assays
      • Cancer Cell Line Panel Screen
      • Biomarker Analysis
    • In Vitro Biology
      • Kinases
      • Epigenetics
      • GPCR, NR, Ion-channel, Transporter
      • Ubiquitin & PROTAC
      • KRAS
      • COVID-19
      • Radiometric
      • Customized assay development
      • High throughput screening
      • MOA Study
    • Metabolic & Cardiovascular Diseases
  • DMPK / Exploratory Toxicology
    • DMPK / Exploratory Toxicology
      • In vitro ADME
      • Pharmacokinetics
      • Exploratory Toxicology
      • Bioanalysis
      • Regulatory filing
    • Biomarkers, Preclinical & Clinical Sample Bioanalysis
    • Large molecule PK/BA services
      • Monoclonal Antibodies
      • Antibody Drug Conjugates
      • Bispecific Antibodies
      • Proteins & Peptides
      • Immunogenicity
  • Biologics Discovery
    • Antibody Discovery
      • Hybridoma
      • Antibody Engineering
      • Phage Display
      • Antibody-Drug Conjugate
    • Protein Science
    • Biologics Analytical Services
      • mAb Release Tests and Extended Characterization
      • Antibody-Drug Conjugate(ADC) Analysis
      • Therapeutic Protein Characterization
      • Biomolecular Interaction Analysis
    • B Cell Cloning
  • Biologics CMC
    • Stable Cell Line Development
    • Process Development
    • Formulation Development
    • Aseptic Filling and Freeze-drying
    • Drug Developability / Manufacturability study
    • Final Container Extractables & Leachables Study
    • Analytical Development and Testing
    • GMP Production
  • Small Molecule CMC
    • Process R&D Services
    • Process Safety
    • Analytical Development
    • Pre-Formulation Development
    • Formulation Development
    • ICH Stability Studies
    • CMC CTD Support
    • Manufacturing

Give us a Message

You can leave us a message by quick contact box and we'll get back to you, asap. Thanks!

Send Message

Logo

ChemPartner is a leading research organization providing high-quality and cost-effective services for the pharmaceutical and biotechnology industry.

Get started today.

Contact Us
  • Shanghai ChemPartner Co., Ltd.
  • 1F & 3F, Block A, 2829 JinKe Road, Zhangjiang Hi-Tech Park, PuDong New Area, Shanghai China, 201203
  • +86 21 5132 0088
  • contact@chempartner.com

© 2021 — Shanghai ChemPartner Co., Ltd. All Rights Reserved  About Us  Careers  Contact Us  Privacy Policy  Sitemap

  • Home
  • Contact
  • Buy Highend