mAb Release Tests and Extended Characterization

Intact mAb analysis

• Intact mass analysis (including heavy chain, light chain, Fab, Fc, etc.)
• Glyco-profiling analysis
• Aggregation analysis
• Charge variant analysis

Intact Mass Analysis (LC-MS)

Glyco-Profiling Analysis (LC-MS)

Aggregation (SEC LC) & Charge Variant Analysis (CEX LC)

Peptide Mapping and PTM Study

• Sequence coverage analysis
• PTM (oxidation, deamidation, N-terminal pyroglutamate formation, glycosylation, etc.) site identification and occupancy analysis
• Disulfide bond confirmation

Peptide Mapping (UPLC&LC-MS/MS)

Sequence coverage map

PTM Analysis (LC-MS/MS)

Glycan Profiling Analysis

• Glycoform identification
• Glycan quantitation